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Analysis of Samples from the Gulf of Mexico Oil Spill by GCxGC-TOFMS
20 Jul 2010: The recent oil spill off the coast of Louisiana, in the Gulf of Mexico, is the largest oil spill in US history. The ability to identify the chemical make-up oil samples from this spill will be an important tool utilized by those responding to this event. This application note demonstrates the ability of LECO's Pegasus 4D GCxGC-TOFMS system to identify a large number of components in a single analysis.
LECO Corp.
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Recent articles: |
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Analysis of Triazine Herbicides in Water Using LC-MS/MS and TraceFinder Software
12 Jul 2010: In this application note, TraceFinder software was used in conjunction with an online preconcentration system, EQuan™, for the robust and reproducible analysis of large volumes of drinking water. Triazines were quantitated at the sub-ppt level, and several commercial bottled drinking water samples and one sugar-free soda sample were analyzed for the presence of triazines.
Thermo Fisher Scientific
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Characterization of Ion Channels in Stem Cell-derived Cardiomyocytes on An Automated Parallel Patch Clamp System
22 Jun 2010: In this application note Molecular Devices use the PatchXpress 7000A automated parallel patch clamp system is used to record Na, K and Ca currents from stem cell-derived mouse cardiomyocytes. The collaborative effort demonstrates that the combination of “ready-to-use” cardiomyocytes with an automated patch clamp system offers a powerful assay platform for fast assessment of compound efficacy and for safety profiling of lead compounds in a biologically relevant system.
Molecular Devices
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Expansion and Differentiation of H7 Human Embryonic Stem Cells in Chemically Defined Medium Using Corning® Synthemax™ Surface
21 Jun 2010: In this application note Corning Synthemax Surface is used to support long-term self-renewal and differentiation of H7 hESCs. Cells demonstrated a stable doubling time, high level of expression of hESC phenotypic markers (Oct4, SSEA4 and TRA-1-60) and normal karyotype. Corning Synthemax Surface also supported successful directed differentiation of H7 cells into functional cardiomyocytes, proving suitability of Corning Synthemax Surface for both expansion and differentiation of hESC culture.
Corning Life Sciences
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Monitoring of Nickel Sulfate, Hypophosphite and Alkalinity in Electroless Nickel Plating Baths
07 Jun 2010: The ProcessLab atline analysis system presented in this application note permits the direct determination of the nickel sulfate and hypophosphite concentrations as well as the alkalinity in electroless nickel plating baths. All relevant process parameters are available immediately after sampling and allow an exact replenishment of consumed bath components.
Metrohm AG
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Cytotoxicity in Cells: Easy Determination Using Lonza ViaLight Plus and ToxiLight BioAssays on the SpectraMax L Microplate Luminometer
07 Jun 2010: The Lonza ViaLight® Plus and ToxiLight® Bioluminescent Cytotoxicity Assays exploit the cell characteristics of ATP levels and adenylate kinase release respectively, as cytotoxicity measures and enable detection using bioluminescent methods. This application note demonstrates that the SpectraMax L Microplate Luminometer and SoftMax Pro Software from Molecular Devices combine well with both assays providing a fast and sensitive combination of technologies in the field of cell death.
Molecular Devices
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Using EL406™ Combination Washer Dispenser to Semi-Automate an ELISA for Melamine
24 May 2010: Melamine is a nitrogen rich compound that has been used illegally as an additive that mimics protein in foods. This application note demonstrates the ability of the EL406 to automate the liquid handling tasks required to run the melamine ELISA kit from Abraxis. The melamine ELISA has the capability to detect melamine contamination in the parts per billion (PPB) ranges.
BioTek Instruments, Inc.
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Natural Products Targeting Oncology Pathways
04 May 2010: In this application note, BioFocus present three examples for natural compounds targeting specific tumor pathways: geldanamycin, borrelidin and fredericamycin. Gram quantities of the compounds are generated using microbial producers and semi-synthesis subsequently generates focused libraries of natural compound analogs. In vivo and in vitro protocols are then used to test potential anticancer properties of the compounds.
BioFocus
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Epigenetics Targets –Efficient Hit-Finding Approaches
04 May 2010: In this application note BioFocus use epigenetic targets to identify starting points for lead optimizaton. In order to address a broad range of novel epigenetics targets, rather than screening a full compound collection, BioFocus use computational chemistry workflows which are individually tailored and optimized for selecting the most suited compounds from library subsets for primary screening. These filtered high-throughput screens generate a greatly increased hit-rate.
BioFocus
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Are Natural Products Delivering? Experiences and Recommendations from 27 Screening Campaigns
04 May 2010: In this application note from BioFocus, microbial strain subfractions are generated and used in high-throughput screens (HTS) for analysis with regard to diversity, selectivity and strain origin. Natural compounds were identified during the follow up of subfraction screening programs and their chemical properties have been analyzed. Searches in natural product databases revealed that 135 of the 645 identified natural compounds are novel compounds.
BioFocus
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chem / bioinformatics
BioTek’s Synergy H4™ Hybrid Reader is LanthaScreen® Plus Certified 
Application Data from Recent Oil Spill to Help Determine the Environmental Impact 
